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7 Supplements To Consider for Weight Loss 1. Caffeine or Green Tea/Extract (Matcha) This is one of the quickest and most easily accessible supplements for weight loss. Caffeine can boost the metabolic rate and increase fat burning. However, people become tolerant to the effects, and as such its impact will slowly diminish. Four prescription weight-loss drugs are approved by the U.S. Food and Drug Administration (FDA) for long-term use: bupropion-naltrexone (Contrave), liraglutide (Saxenda), orlistat (Xenical) and phentermine-topiramate (Qsymia). Most prescription weight-loss drugs work by decreasing appetite or increasing feelings of fullness, and some do both.
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